These custom adaptive reducers follow International Standards Organization (ISO) standards and have a flange size of NW-100 ISO-K 100 to Conflat 8.0 non-rotatable. ISO flanged vacuum fittings are commonly used to build process vacuum plumbing and systems for industrial applications. Conflat flanges use a copper gasket and knife-edge flanges to achieve the high vacuum seal and can operate down to 10-13 torr (10-11 Pa). The Viton® centering ring contains a rubber/elastomeric o-ring. The ISO standard sizes for large flanges are NW-63, NW-80, NW-100, NW-160, NW-200, NW-250, NW-320, NW-400, NW-500, NW-630. These vacuum flanges are made of stainless steel.